Endocrine Abstracts

Background: Insulin gene (INS) is known to be responsible for production of insulin by the pancreatic β-cells. It includes variable number of tandem repeats (VNTR) of oligonucleotide consequence (ACAGGGGT (G/C) (T/C) GGGG) in the promoter region (Bell et al, 1981,1982); being the gene involved in the susceptibility to various pathologies. The allele-specific PCR allows direct diagnosis of some genetically determined disorders is rather simple and precise. However, by toda...

Diabetes mellitus (DM) is a most significant medical-social worldwide problem. Absence of reliable screening program for identification of persons with the higher risk of DM dictates a necessity of sensitive tests of early DM diagnosis. Following genealogical analysis, two experimental groups were formed; patients with type 1 DM with the familial burden (probands) and those at risk (siblings) were included into the 1st and 2nd groups, respectively. Apparently healthy subjects ...